Peyronie's disease is a disorder that can lead to curvature of the penis. Typically a palpable plaque forms on the shaft of the penis within a sheath called the tunica albuginea, leading to the curvature. Causes for Peyronie’s disease are not clearly understood. In many cases, Peyronie's disease results in only mild penile curvature and does not significantly impact sexual function. Sometimes the plaque resolves spontaneously. In other cases, curvature can be severe and can cause difficulty with penetration, painful erection, or difficulty achieving and maintaining erection. A variety of therapies is available for Peyronie's disease. Observation is commonly recommended, as the plaque may resolve spontaneously. Oral medications and supplements have been tried, but limited data support their use. Surgical options include excision of the plaque and placement of a graft or placement of a penile prosthesis.